- Milder symptoms of COVID-19 linked with virus mutation.
- 3-D mapping of key viral proteins.
Genetic variant of virus associated with a milder infection
A new study published this week in the Lancet shows that a mutation in the SARS-CoV-2 virus is linked to milder symptoms than those caused by a virus without the mutation.
The mutation, which causes a deletion of two genes called ORF7b and ORF8, was identified earlier on this year when researchers in Singapore found a cluster of COVID-19 cases caused by the virus with the genetic mutation. The researchers compared the symptoms of those with the mutated version of the virus with symptoms of patients infected by the unmutated version and found that none of the 29 people infected with the mutated version needed supplemental oxygen. By comparison, 28% (26 out of 92) people whose viruses did not have the mutation did need oxygen.
The mutated version of the virus has not been detected since March but the researchers note that the virus responsible for the 2002-2004 outbreak of severe acute respiratory syndrome (SARS) also acquired a mutation that caused a deletion in the ORF8…
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