Home Health Antibody-mediated platelet death linked to COVID-19 severity – News-Medical.Net

Antibody-mediated platelet death linked to COVID-19 severity – News-Medical.Net


Even as the evidence of the central role played by immune dysregulation in severe COVID-19 pours in, the coagulation system is also being seen to be significantly disrupted in this condition. A new study by University of Tuebingen researchers published on the preprint server medRxiv* in September 2020 shows the strong association between platelet apoptosis and the thrombotic manifestations that may underlie critical COVID-19 illness.

Procoagulant Activity in COVID-19

It is now established that coagulation activity is high in COVID-19 patients who require intensive care. However, it does not seem to fit the definition of disseminated intravascular coagulation (DIC), nor is it the kind of perturbed clotting seen in severe infections. DIC was identified only in severe or critical COVID-19.

However, scientists also noticed that patients with severe COVID-19 in the ICU also had acute clotting manifestations in the lung (pulmonary embolism, PE), ischemic stroke, deep vein thrombosis (DVT), myocardial infarctions, and clots forming in the systemic arteries, in half the patients. Thus, thromboembolism and infection with severe acute respiratory syndrome coronavirus 2…

Read More: https://www.news-medical.net/news/20200907/Antibody-mediated-platelet-death-linked-to-COVID-19-severity.aspx

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Source: https://www.news-medical.net/news/20200907/Antibody-mediated-platelet-death-linked-to-COVID-19-severity.aspx

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